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Serial-block-face scanning electron microscopy (SBFSEM) has revolutionized electron microscopy of cellular ultrastructure by providing a high throughput method to image large fields of view at tens of nanometer (nm) resolution.… Click to show full abstract
Serial-block-face scanning electron microscopy (SBFSEM) has revolutionized electron microscopy of cellular ultrastructure by providing a high throughput method to image large fields of view at tens of nanometer (nm) resolution. These data are enabling scientists to visualize and understand the intricate details of cellular architecture in health and disease. For examples within cardiac physiology, SBFSEM has enabled scientists to visualize the distribution of mitochondria in health and heart failure and examine the distribution of the sarcoplasmic reticulum.
Journal Title: Microscopy and Microanalysis
Year Published: 2017
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