The development of direct electron detector technology [1,2] has led to a revolution in the field of cryo electron microscopy, [3] leading to dramatic enhancements in image resolution. [4] These… Click to show full abstract
The development of direct electron detector technology [1,2] has led to a revolution in the field of cryo electron microscopy, [3] leading to dramatic enhancements in image resolution. [4] These detectors provide a greatly enhanced detective quantum efficiency, which can lead to both high image acquisition speeds and operation in low-dose modes wherein every electron that strikes the detector is counted (“counting mode”).
               
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