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Contraction of skeletal and cardiac muscles is triggered by transient increase of cytosolic Ca concentration. Such Ca transient is originated from the massive release of Ca stored in the sarco/endoplasmic… Click to show full abstract
Contraction of skeletal and cardiac muscles is triggered by transient increase of cytosolic Ca concentration. Such Ca transient is originated from the massive release of Ca stored in the sarco/endoplasmic reticulum (SR), via intracellular Ca channels known as the ryanodine receptors (RyRs). Functional Ca release units formed by discrete clusters of multiple RyRs open synchronously upon activation of plasmalemmal voltage-gated Ca channels. A different subcellular anatomy of the cardiac and skeletal muscle cells, and two different RyR isoforms (RyR1 in skeletal muscle and RyR2 in heart), result in fundamentally different temporal and spatial Ca release profiles [1, 2].
Journal Title: Microscopy and Microanalysis
Year Published: 2018
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