LAUSR

Skin is the largest organ that includes multiple layers with important functions such as an environmental and antimicrobial barrier, thermal regulation, and fat storage. Bone is similarly important and serves and provides the structure support for containing all other organs and tissues. We explore the possibility of autologous homologous constructs to neo-generate a variety of fully functional tissue types to treat various clinical indications. Examining the ultrastructure and function of native tissue is crucial to produce a method to regenerate tissue similar in architecture and function to native tissue. To achieve this aim, we utilized correlative microscopy to analyze native, conventionally treated, naturally healed, and autologous homologous skin construct (AHSC) and autologous homologous bone construct (AHBC) treated tissues.