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The dynamic, three-dimensional chromatin organization plays an important role in regulating a vast number of cellular processes, including cell-type-specific gene expression and lineage commitment (1-3). Large-scale alterations in chromatin structure… Click to show full abstract
The dynamic, three-dimensional chromatin organization plays an important role in regulating a vast number of cellular processes, including cell-type-specific gene expression and lineage commitment (1-3). Large-scale alterations in chromatin structure are associated with cancer, numerous neurological and autoimmune disorders, and other complex diseases (4, 5). Extending across multiple length-scales from the nucleosome to higher-order three-dimensional structures chromatin is a dynamic system which evolves throughout the lifetime of a cell. However, the precise conformation of chromatin and its relationship with transcription, a direct determinant of cellular phenotype, remains contested.
Journal Title: Microscopy and Microanalysis
Year Published: 2020
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