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Multivesicular liposome (MVL) is a lipid-based drug delivery system that provides sustained release of drugs with short half-lives. To date, three MVL-based drug products have been approved by the FDA.… Click to show full abstract
Multivesicular liposome (MVL) is a lipid-based drug delivery system that provides sustained release of drugs with short half-lives. To date, three MVL-based drug products have been approved by the FDA. The objective of this study was to identify the suitable labeling agent for the MVL which would allow non-destructive imaging of the MVL internal structure and morphology using Confocal Laser Scanning Microscopy (CLSM). In addition, the effect of critical manufacturing process parameters on the structure and morphology of bupivacaine MVL was also evaluated.
Journal Title: Microscopy and Microanalysis
Year Published: 2020
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