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The most common remedy for reduced or obstructed circulation is balloon angioplasty. While acutely effective, the treatment causes restenosis in a high fraction of patients via neointimal lesions. A significant… Click to show full abstract
The most common remedy for reduced or obstructed circulation is balloon angioplasty. While acutely effective, the treatment causes restenosis in a high fraction of patients via neointimal lesions. A significant barrier to unravelling the mechanisms of restenosis concerns the dynamic spatial profiling of bioactive lipids in the arterial wall [1]. Applying matrix-assisted laser desorption-ionization (MALDI) and time-offlight secondary ion mass spectrometry (TOF-SIMS) imaging, we conducted a first spatiotemporal lipidomic study of angioplasty-induced restenosis in a small animal model. The MS imaging data revealed that diacylglycerol (DG) and lyso-phosphatidylcholine (LPC) signals increased within the neointima layer of the 7and 14-day injured specimens compared to the controls, while sphingomyelin (SM) signals decreased versus the controls.
Journal Title: Microscopy and Microanalysis
Year Published: 2020
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