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Enabling a Paradigm Shift in CryoEM Sample Preparation with chameleon

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The period responsible for the current generation of cryogenic electron microscopy (cryo-EM) instrumentation and image processing software is often referred to as the “resolution revolution.” The results of these technological… Click to show full abstract

The period responsible for the current generation of cryogenic electron microscopy (cryo-EM) instrumentation and image processing software is often referred to as the “resolution revolution.” The results of these technological advancements have been achievements in higher quality structures and cryo-EM becoming the go-to method for structural biologists. However, sample preparation is widely recognised as a key unresolved step in the high-resolution cryo electron microscopy (cryoEM) workflow [1].

Keywords: paradigm shift; microscopy; cryoem; enabling paradigm; sample preparation

Journal Title: Microscopy and Microanalysis
Year Published: 2021

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