LAUSR

Single entity sensing is recently an area of tremendous inter-est in analytical chemistry, such that it is possible to analyze single cells, single particles, and even single molecules. Among diverse analytical methods, the electrochemical method is at the heart of single entity sensing, because it is capable of precisely monitoring the process of elec-tron/charge transfer by a designable and controllable sensing interface whose size is comparable with that of single entities. Then, a fair question follows: How do electrochemical tech-niques achieve single entity sensing? To answer this question, there is an urgent demand to introduce a concept, that is, confined space.