LAUSR

Hypochlorous acid (HClO), as an important reactive oxygen species (ROS), plays a crucial role in our daily life and in biological systems, and its convenient and accurate detection is significant and imperative. In this work, a self-calibrated multimode optical sensor for convenient and accurate HClO detection was elaborately fabricated based on a multifunctional metal-organic framework platform with catalytic active metal nodes, fluorescent responsive bridging ligands, and intrinsic pores for functional molecule accommodation. The sensor shows not only turn-on and ratiometric fluorescence response but also color change in response to HClO. The detection limits are as low as 16.9, 17.3, 66.5, and 63.2 nM for ratiometric fluorometry, absorbance-based colorimetry, and smartphone-based fluorescenceand color analysis, respectively. The accuracy and practicability of this sensor were also demonstrated by the detection of hypochlorous acid in actual water and body fluid samples, and the recovery rates ranged from 97.8 to 103.8%.