LAUSR

Due to exceptional electron-accepting ability, light-absorption and delocalized conjugated structure, buckminsterfullerene (C60) has attracted fascinating interests in the field of organic solar cells. However, poor delocalization and accumulation of electrons for pristine C60 in physiological aqueous solution and difficulties in conjugation with biomolecules limit its extended photovoltaic ap-plications in bioassay. Herein, we reported the non-covalent coupling of C60 to an electronically complementary porphyrin-derived metal-organic framework (PCN-224) with carboxyl-group terminals. Such assembly not only offered a friendly interface for biocon-jugation but also resulted in a long-range ordering C60@PCN-224 donor-acceptor system that demonstrated an unprecedented pho-tocurrent enhancement up to 10 times with respect to each component. As an example, by further cooperating with Nanobodies, the as-prepared C60@PCN-224 was applied to a photoelectrochemical (PEC) immunosensor for S100 calcium-binding protein B with by far the most promising detection activities. This work may open a new venue to unlock the great potential of C60 in PEC bio-sensing with excellent performances.