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Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid-amine reagents can be… Click to show full abstract
Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid-amine reagents can be transformed directly to the respective amide products under these edited Kinugasa reaction conditions. 3-Cycle DNA-encoded libraries (DELs) can be built in three steps of chemical conversion.
Keywords:
amidation terminal;
dna compatible;
compatible oxidization;
terminal alkynes;
amidation;
oxidization amidation
Journal Title: Bioconjugate chemistry
Year Published: 2022
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Journal Title: Bioconjugate chemistry
Year Published: 2022
Link to full text (if available)
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recommendations!