LAUSR

Developing permanent antibacterial and rapid hemostatic wound dressings with excellent biocompatibility is urgently needed and has always gained great attention. Here, a series of amino acid-derived pseudoprotein consisting of poly(ester amide) (PEA)-based hydrogel dressings and three types of cationic short peptides (RGDK, RRRFK, and RRRFRGDK) are prepared. Compared with the antibacterial segments containing hydrogel scaffolds, the method of peptide modification of surface possesses the minimal usage of antibacterial moiety due to the effective contacting wound spots. Direct peptide RRRFRGDK (P3) conjugation to the hydrogel surface through an amidization reaction can enhance the antibacterial and hemostatic abilities with no or minimal outer appearance and inner morphology damage to the original hydrogels. The P3-functionalized hydrogel (Gel-g-P3) presents excellent water uptake capacity, robust mechanical strength, enzymatic biodegradation, good hemocompatibility, and cytocompatibility. Moreover, the Ge...