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Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and… Click to show full abstract
Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.
Keywords:
protein;
molecule modulation;
protein homeostasis;
control;
small molecule;
modulation protein
Journal Title: Chemical reviews
Year Published: 2017
Link to full text (if available)
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Journal Title: Chemical reviews
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!