LAUSR

In the fine and pharmaceutical chemical industries, designing thermally safe operating conditions for liquid–liquid semibatch reactors (SBRs) is a very important issue to prevent the occurrence of thermal runaway. However, because of the time and money constraints in determining the kinetic and solubility parameters for liquid–liquid reactions in practice, it is essential to develop a kinetic-parameters-free and solubility-parameter-free procedure to determine thermally safe operating conditions for liquid–liquid SBRs. In this work, the primary contribution is to develop a simple procedure, with no requirement of kinetic and solubility parameters, to designing thermally safe operating conditions for liquid–liquid SBRs in which kinetically controlled liquid–liquid reactions occur. For this purpose, a modified definition of QFS operation is proposed first. Then, a series of theoretical tools based on the modified definition of QFS operation are developed to design thermally safe operating conditions. Finall...