Photo from wikipedia
The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the… Click to show full abstract
The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.
Keywords:
serum transferrin;
cisplatin binding;
human serum
Journal Title: Inorganic Chemistry
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Inorganic Chemistry
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!