Bidentate Pt(II) complexes with cyclometalated N-heteroarene or N-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF2H)… Click to show full abstract
Bidentate Pt(II) complexes with cyclometalated N-heteroarene or N-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF2H) into the wingtip of NHCs, where CF2H acts as a lipophilic hydrogen bond (HB) donor. Their cyclometalated Pt(II) complexes show excellent PLQYs (up to 93%) and phosphorescence lifetimes mainly due to the rigid structure with hydrogen bonding between the CF2H group and the adjacent O atom at the β-diketonate ligand. Bioimaging studies demonstrate high cellular uptake efficiency and deep tumor penetration capability of complex 7 in HeLa cells and multicellular tumor spheroids, highlighting their potential as bioimaging probes.
Journal Title: Inorganic chemistry
Year Published: 2024
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