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In this study, sugary maize dendrimer-like glucan (SMDG) was used as a delivery carrier for improving the bioavailability of resveratrol (RES). After optimization, the solubility of RES in RES-SMDG markedly… Click to show full abstract
In this study, sugary maize dendrimer-like glucan (SMDG) was used as a delivery carrier for improving the bioavailability of resveratrol (RES). After optimization, the solubility of RES in RES-SMDG markedly increased to approximately 9.1 times that of raw RES solution. The structural characterizations of RES-SMDG formulation showed crystal RES was entrapped in SMDG matrix for amorphous state due to the strong intermolecular hydrogen bonds between -OH of RES and glucan chains. In this case, antioxidant activity of RES-SMDG was markedly higher than that of raw RES solution. In the Caco-2 cell model, the Papp value of RES in RES-SMDG group was slightly higher than common permeable compounds, while the cellular uptake was significantly improved. RES-SMDG also exhibited protective effects against cellular damage under oxidative stress. The results indicated that SMDG is an attractive carrier to encapsulate and protect hydrophilic bioactive ingredients.
Journal Title: Journal of agricultural and food chemistry
Year Published: 2020
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