LAUSR

This study assessed the impact of caffeic and ferulic acid complexation with maize amylopectin or potato starch on glycemic parameters. Compared with starch-phenolic mixtures, starch-phenolic complexes resulted in significant modification of phenolic bioaccessibility and cellular uptake (p < 0.05). In addition, glucose release from in vitro digestion of starch was modestly reduced in the complexes compared to native starch alone (21.2-26.8mM vs. 29.8-30.5mM). Furthermore, intestinal glucose transport, assessed in Caco-2 cell monolayers was not affected by presence of complexes (82.4-124% vs. 100% at 90 min). However, a reduced glycemic response was evident in a Wistar rat model with significant reduction in 240 min blood glucose AUC following oral administration of potato starch-ferulic acid complex compared to native potato starch (26170±556 vs. 28951±486 mg*min/dL, p < 0.001). These alterations were attributed to complexation-induced resistant starch formation and phenolic entrapment providing an alternative mechanism approach to modulate glycemic properties of starch-based foods.