LAUSR

Setting regulatory limits for arsenic in food is complicated owing to the enormous diversity of arsenic metabolism in humans, lack of knowledge about the toxicity of these chemicals, and lack of accurate arsenic speciation data on foodstuffs. Identification and quantification of the toxic arsenic compounds is imperative to understanding the risk associated with exposure to arsenic from dietary intake, which in turn underscores the need for speciation analysis of the food. Arsenic speciation in seafood is challenging owing to its existence in myriads of chemical forms and oxidation states. Interconversions occurring between chemical forms, matrix complexity, lack of standards and certified reference materials, and lack of widely accepted measurement protocols present additional challenges. This review covers the current analytical techniques for diverse arsenic species. The requirement for high quality arsenic speciation data that is essential for establishing legislation and setting regulatory limits for arsenic in food is explored.