LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Phase Separation of Amphiphilic Drug Amitriptyline Hydrochloride in the Presence of Additives: Role of Ethanol

Photo from wikipedia

In this work, the effect of ethanol (EtOH) at different weight percentages (wt %) (0, 5, 10, and 15% w/w) is accounted for in the clouding phenomena of the AMT… Click to show full abstract

In this work, the effect of ethanol (EtOH) at different weight percentages (wt %) (0, 5, 10, and 15% w/w) is accounted for in the clouding phenomena of the AMT drug with/without additives (inorganic salts and conventional and gemini surfactants). The critical micelle concentration (cmc) and degree of counterions dissociation (α) of AMT solution at 30 °C in SP buffer (pH 6.7), studied through conductometric studies, are found to be enhanced with the increase in ethanol content due to the reduction in the dielectric constant of mixed media. A dye solubilization study performed under identical physicochemical conditions exhibited supporting results. Clouding could not be observed in 20 wt % EtOH–WR mixed media at pH 6.7. The effects of additives on the CP in 15 wt % EtOH–WR at a pH of 6.95 were also studied. Furthermore, the effect of pH (range 6.7 to 7.15) on the CP in the presence of KCl at the same composition of the mixed media reduce the clouding temperature due to the deprotonation of AMT headgroups. F...

Keywords: phase separation; presence; drug; separation amphiphilic; amphiphilic drug; mixed media

Journal Title: Journal of Chemical & Engineering Data
Year Published: 2018

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.