The solubility of imatinib mesylate in nine monosolvents and two binary solvents was determined by the shaken flask method followed by UV composition analysis from 278.15 to 318.15 K at… Click to show full abstract
The solubility of imatinib mesylate in nine monosolvents and two binary solvents was determined by the shaken flask method followed by UV composition analysis from 278.15 to 318.15 K at atmospheric pressure. The solubility increases with the increasing of temperature in all solvents we chose. Meanwhile, the dissolving capacity of imatinib mesylate ranks as methyl acetate < 2-propanol < acetonitrile < isobutanol < 1-butanol < tetrahydrofuran < 1-propanol < ethanol < methanol. The Apelblat model, λh equation, and nonrandom two-liquid (NRTL) model described the solubility data of imatinib mesylate in monosolvents; simultaneously, the Apelblat model, combined nearly ideal binary solvent/Redlich-Kister model, and NRTL model were employed in binary solvents. The results show a satisfactory correlation with the experimental data. Additionally, mixing thermodynamic properties of imatinib mesylate were calculated based on the NRTL model, which reveals the mixing process is spontaneous and exothermic.
               
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