LAUSR

In this work, the solid–liquid equilibrium for levetiracetam in 10 neat solvents (methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene, and cyclohexane) and binary liquid mixtures (ethanol + ethyl acetate) was measured by using a static gravimetric method at temperatures T = 283.15–323.15 K under pressure of 101.2 kPa. In general, the equilibrium solubility was highest in methanol and lowest in cyclohexane. The modified Apelblat equation, λh equation, Wilson model, and NRTL model were used to correlate the solubility data in monosolvents; and the Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and Apelblat–Jouyban–Acree model were used to correlate the experiment data in the binary solvent mixtures. Compared with the results of the above models, the calculated solubility provided good results with the experimental data. Consequently, for the monosolvents, the values of root-mean-square deviation and relative average deviation were not exceeding 9.91 ×...