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Only one FDA-approved β-lactamase inhibitor has ever been orally available: clavulanic acid, approved in 1984. Avibactam, approved by FDA in 2015, is the first of a new class of BLIs… Click to show full abstract
Only one FDA-approved β-lactamase inhibitor has ever been orally available: clavulanic acid, approved in 1984. Avibactam, approved by FDA in 2015, is the first of a new class of BLIs called diazabicyclooctanes, or "DBOs". This class has much broader coverage than clavulanic acid but can only be administered by intravenous injection. Herein, we describe the synthesis and testing of the first approved BLI to be rendered orally bioavailable since clavulanic acid (1984).
Keywords:
inhibitor;
clavulanic acid;
lactamase inhibitor;
orally absorbed;
absorbed derivatives;
avibactam
Journal Title: Journal of medicinal chemistry
Year Published: 2018
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Journal Title: Journal of medicinal chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!