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Penisarins A (1) and B (2), sesquiterpene coumarins with an unusual tricyclic sesquiterpene system, were isolated from endophytic Penicillium sp. KMU18029. Their structures were elucidated on the basis of spectroscopic… Click to show full abstract
Penisarins A (1) and B (2), sesquiterpene coumarins with an unusual tricyclic sesquiterpene system, were isolated from endophytic Penicillium sp. KMU18029. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 2 showed significant cytotoxicities against two human cancer cell lines, HL-60 and SMMC-7721, with IC50 values of 3.6 ± 0.2 and 3.7 ± 0.2 μM, respectively.
Keywords:
endophytic penicillium;
penisarins sesquiterpene;
sesquiterpene coumarins;
coumarins isolated;
isolated endophytic
Journal Title: Journal of natural products
Year Published: 2020
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Journal Title: Journal of natural products
Year Published: 2020
Link to full text (if available)
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recommendations!