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A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and… Click to show full abstract
A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.
Keywords:
cyclic tetrapeptide;
nocardiopsis;
marine;
tetrapeptide marine;
androsamide cyclic;
motility
Journal Title: Journal of natural products
Year Published: 2020
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Journal Title: Journal of natural products
Year Published: 2020
Link to full text (if available)
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recommendations!