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The originally proposed structure of astakolactin was revised, and an asymmetric total synthesis of the newly proposed structure was achieved. The key transformations in the synthesis were a Johnson-Claisen rearrangement,… Click to show full abstract
The originally proposed structure of astakolactin was revised, and an asymmetric total synthesis of the newly proposed structure was achieved. The key transformations in the synthesis were a Johnson-Claisen rearrangement, an asymmetric Mukaiyama aldol reaction, and a Mitsunobu-type cyclodehydration. The spectroscopic data and specific rotation of the compound obtained matched well with those reported for naturally occurring astakolactin.
Keywords:
asymmetric total;
total synthesis;
astakolactin confirmation;
synthesis astakolactin
Journal Title: Journal of natural products
Year Published: 2017
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Journal Title: Journal of natural products
Year Published: 2017
Link to full text (if available)
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recommendations!