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Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B… Click to show full abstract
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10' and C-2-O-C-9'. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
Keywords:
aspidosperma bisindole;
bisindole alkaloids;
bisleuconothines modified;
eburnane aspidosperma;
modified eburnane;
leuconotis griffithii
Journal Title: Journal of natural products
Year Published: 2018
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Journal Title: Journal of natural products
Year Published: 2018
Link to full text (if available)
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recommendations!