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Nine new limonoids, meliazedarines A-I (1-9), seven known analogues (10-16), and five known triterpenoids (17-21) were isolated from the fruits of Melia azedarach. Their structures were determined by analysis of… Click to show full abstract
Nine new limonoids, meliazedarines A-I (1-9), seven known analogues (10-16), and five known triterpenoids (17-21) were isolated from the fruits of Melia azedarach. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, and electronic circular dichroism (ECD) data. Compound 7 showed significant cytotoxicity against the HCT116 cell line with IC50 values of 0.3 ± 0.1 μM.
Keywords:
triterpenoids fruits;
fruits melia;
bioactive limonoids;
melia azedarach;
limonoids triterpenoids
Journal Title: Journal of natural products
Year Published: 2020
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Journal Title: Journal of natural products
Year Published: 2020
Link to full text (if available)
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recommendations!