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respectively). As shown in Table 1, the correct RAF1B1 and RAF1B3 values for lot OJE were 3.65 and 0.627, respectively, which provided the CLuptake,1B1+1B3,RAF values in the amended Table 3… Click to show full abstract
respectively). As shown in Table 1, the correct RAF1B1 and RAF1B3 values for lot OJE were 3.65 and 0.627, respectively, which provided the CLuptake,1B1+1B3,RAF values in the amended Table 3 shown herein. By using the correct RAF1B1 and RAF1B3 values, the contribution of OATP1B1 ranged from 86.4% (fexofenadine) to 99.3% (torasemide) in lot OJE. RAF-based net uptake clearance mediated by OATP1B1 and OATP1B3 (CLuptake,1B1+1B3,RAF) was predictive of human hepatocyte PSinf,act values within or close to 3-fold errors in lot OJE, in which the PSinf,act values of fexofenadine and fluvastatin were 3.9and 3.3-fold greater than the CLuptake,1B1+1B3,RAF values, respectively. We have confirmed that the calculation errors
Journal Title: Molecular pharmaceutics
Year Published: 2020
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