We have demonstrated the efficient chiral analysis of fluorine-containing compounds by 19F NMR spectroscopy. The highly sensitive fluorine nucleus allowed chiral analysis of complex mixtures and even asymmetric reaction mixtures… Click to show full abstract
We have demonstrated the efficient chiral analysis of fluorine-containing compounds by 19F NMR spectroscopy. The highly sensitive fluorine nucleus allowed chiral analysis of complex mixtures and even asymmetric reaction mixtures of multisubstrates. A single 19F NMR experiment was sufficient to determine the enantiomeric excesses and yields of the five products simultaneously.
               
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