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Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe.

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A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation.… Click to show full abstract

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

Keywords: bromides bbn; aryl bromides; catalyzed methoxylation; bbn ome; copper catalyzed

Journal Title: Organic letters
Year Published: 2021

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