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Synthesis of 10-Aza-9-oxakalkitoxin by N-O Bond Formation.

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We describe a formal synthesis of 10-aza-9-oxakalkitoxin, the hydroxalog of the cytotoxic marine natural product kalkitoxin, that features Mukaiyama Markovnikov silyl peroxidation of a terminal alkene and N-O bond formation… Click to show full abstract

We describe a formal synthesis of 10-aza-9-oxakalkitoxin, the hydroxalog of the cytotoxic marine natural product kalkitoxin, that features Mukaiyama Markovnikov silyl peroxidation of a terminal alkene and N-O bond formation as the central enabling steps.

Keywords: aza oxakalkitoxin; synthesis aza; bond formation

Journal Title: Organic letters
Year Published: 2022

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