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Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes

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Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present… Click to show full abstract

Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present a bioinspired cobalt-catalysis-based strategy to access unprecedented modes of radical reactivity via oxetane ring-opening. This powerful approach gives access to nucleophilic radicals that engage in reactions with SOMOphiles and low-valent transition metals. Importantly, the regioselectivity of these processes complements known methodologies.

Keywords: catalysis enables; cobalt catalysis; nucleophilic radicals; bioinspired cobalt; enables generation

Journal Title: Organic Letters
Year Published: 2022

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