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Herein, we report the first diaryliodonium salts promoted multicomponent 1,2,3-trifunctionalization of alkynes, where both the acetylenic bond and the adjacent nonactivated propargylic C(sp3)-H bond were functionalized synergistically to generate α-arylated… Click to show full abstract
Herein, we report the first diaryliodonium salts promoted multicomponent 1,2,3-trifunctionalization of alkynes, where both the acetylenic bond and the adjacent nonactivated propargylic C(sp3)-H bond were functionalized synergistically to generate α-arylated enones with high chemo-, regio-, and stereoselectivity. A broad spectrum of diaryliodonium salts and internal alkynes could be utilized in this protocol, and a diverse collection of highly substituted and stereochemically defined linear and cyclic complex structures could be elaborated from the enone products.
Journal Title: Organic letters
Year Published: 2022
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