An atom-economic protocol for the efficient and highly chemo- and stereoselective trans-hydroarylation of ynamides with hydroxyarenes catalyzed by B(C6F5)3 has been developed. Use of readily available starting materials, low catalyst… Click to show full abstract
An atom-economic protocol for the efficient and highly chemo- and stereoselective trans-hydroarylation of ynamides with hydroxyarenes catalyzed by B(C6F5)3 has been developed. Use of readily available starting materials, low catalyst loading, mild reaction conditions, a broad substrate scope, ease of scale-up, and versatile functionalizations of the enamide products make this approach very practical and attractive.
               
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