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The catalytic asymmetric synthesis of chiral compounds with multiple stereogenic elements via a single catalytic process is challenging. This paper proposes a domino asymmetric electrophilic halocyclization strategy for constructing heterocycloalkenyl… Click to show full abstract
The catalytic asymmetric synthesis of chiral compounds with multiple stereogenic elements via a single catalytic process is challenging. This paper proposes a domino asymmetric electrophilic halocyclization strategy for constructing heterocycloalkenyl atropisomeric spiroketal lactones. A single catalyst was utilized to realize two independent stereodetermining steps. Various spiroketal lactones containing both chiral axes and chiral centers were prepared in excellent yields with excellent enantioselectivity and diastereoselective (up to 99% ee and >20:1 dr).
Journal Title: Organic letters
Year Published: 2022
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