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Aryl perfluorocyclopropyl ethers have been synthesized for the first time by [2 + 1] cyclopropanation between aryl trifluorovinyl ethers and a commercially available TMSCF2Br reagent. This cycloaddition reaction between two… Click to show full abstract
Aryl perfluorocyclopropyl ethers have been synthesized for the first time by [2 + 1] cyclopropanation between aryl trifluorovinyl ethers and a commercially available TMSCF2Br reagent. This cycloaddition reaction between two fluorine-containing reactants proceeds smoothly in toluene at 120 °C in the presence of a catalytic amount of n-Bu4NBr, and the reaction tolerates a variety of functional groups. A wide range of aryl trifluorovinyl ethers, easily accessible from phenols, were successfully transformed to aryl perfluorocyclopropyl ethers.
Journal Title: Organic letters
Year Published: 2022
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