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Synthesis of α-Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis.

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The development of mild and practical conditions for the fluoroalkylation of arenes is an ongoing challenge in chemical organic synthesis. Herein, we report a metallaphotoredox method for the preparation of… Click to show full abstract

The development of mild and practical conditions for the fluoroalkylation of arenes is an ongoing challenge in chemical organic synthesis. Herein, we report a metallaphotoredox method for the preparation of fluoroalkyl arenes based on the synergistic combination of Ir/Cu dual catalysis from boronic acids. The mild conditions allow broad functional group tolerance, including substrates containing aldehydes, free phenols, and N-Boc-protected amines. Mechanistic investigations support a process proceeding via photoredox/copper dual catalysis.

Keywords: catalysis; synthesis fluorinated; dual catalysis; copper dual; photoredox copper

Journal Title: Organic letters
Year Published: 2022

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