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With the continued interest in the properties of the difluoromethyl (CF2H) group, small molecules with alkyl-CF2H motifs have gained increasing attention. However, concise and efficient synthetic protocols to achieve these… Click to show full abstract
With the continued interest in the properties of the difluoromethyl (CF2H) group, small molecules with alkyl-CF2H motifs have gained increasing attention. However, concise and efficient synthetic protocols to achieve these structures are still urgently needed. Herein, we report a new acyldifluoromethylation of inert alkenes via a synergistic NHC-photoredox catalysis featuring broad substrate scope and good functional group tolerance.
Keywords:
enabled nhc;
photoredox cocatalysis;
nhc photoredox;
acyldifluoromethylation enabled
Journal Title: Organic letters
Year Published: 2022
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!