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A Pd(II)-catalyzed synthesis of furopyridines has been developed from β-ketodinitriles and alkynes via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan… Click to show full abstract
A Pd(II)-catalyzed synthesis of furopyridines has been developed from β-ketodinitriles and alkynes via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C═C, C-O, C-N, and C═N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations.
Keywords:
synthesis furo;
alkynes via;
annulation;
ketodinitriles alkynes;
catalyzed synthesis
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!