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A Cost-Effective Way to Produce Gram-Scale 18O-Labeled Aromatic Aldehydes.

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Obtaining 18O-labeled organic substances is of great research importance and also an extremely challenging work. In this work, depending on the reversed Knoevenagel reaction, 18O-labeled aromatic aldehydes (3a-3x) are successfully… Click to show full abstract

Obtaining 18O-labeled organic substances is of great research importance and also an extremely challenging work. In this work, depending on the reversed Knoevenagel reaction, 18O-labeled aromatic aldehydes (3a-3x) are successfully obtained with high total yields (52-72%) and sufficient 18O abundance (90.90-96.09%).

Keywords: labeled aromatic; cost effective; effective way; way produce; 18o labeled; aromatic aldehydes

Journal Title: Organic letters
Year Published: 2022

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