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A photocatalytic three-component reaction of α-trifluoromethyl alkenes, electron-rich alkenes, and sodium sulfinates for the synthesis of gem-difluoroalkenes in a radical/polar crossover manner was developed. Due to the strong electron-withdrawing nature… Click to show full abstract
A photocatalytic three-component reaction of α-trifluoromethyl alkenes, electron-rich alkenes, and sodium sulfinates for the synthesis of gem-difluoroalkenes in a radical/polar crossover manner was developed. Due to the strong electron-withdrawing nature of the sulfonyl group, the resultant gem-difluoroalkenes can be converted into various monofluorocyclopentenes via intramolecular base-mediated SNV reactions in one pot.
Keywords:
trifluoromethyl alkenes;
sodium sulfinates;
component reaction;
three component;
alkenes sodium;
reaction trifluoromethyl
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!