An efficient iridium-catalyzed asymmetric formal [5+1] annulation by in situ generation of enamines as N-nucleophiles for the synthesis of tetrahydropyridine derivatives is disclosed. The methodology offers direct access to a… Click to show full abstract
An efficient iridium-catalyzed asymmetric formal [5+1] annulation by in situ generation of enamines as N-nucleophiles for the synthesis of tetrahydropyridine derivatives is disclosed. The methodology offers direct access to a wide variety of chiral tetrahydropyridine derivatives in moderate to good yields and excellent enantioselectivity.
               
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