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NH-Sulfonimidamides are prepared by copper-catalyzed coupling of primary sulfinamides with secondary amines. Neither a ligand nor an additive is needed, and air is the terminal oxidant. The reactions occur at… Click to show full abstract
NH-Sulfonimidamides are prepared by copper-catalyzed coupling of primary sulfinamides with secondary amines. Neither a ligand nor an additive is needed, and air is the terminal oxidant. The reactions occur at room temperature, show good functional group tolerance, and lead to products in good yields. A sulfanenitrile is proposed as an intermediate in this oxidative amination.
Keywords:
primary sulfinamides;
catalyzed aerobic;
sulfinamides secondary;
secondary amines;
aerobic synthesis;
copper catalyzed
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!