Photo by conscious_design from unsplash
The reaction of alkynyl aryl ketones bearing an o-methoxy group with difluoromethyl sulfoxide in the presence of Tf2O was found to conveniently afford the corresponding 3-SCF2H-substituted chromones. The combining use… Click to show full abstract
The reaction of alkynyl aryl ketones bearing an o-methoxy group with difluoromethyl sulfoxide in the presence of Tf2O was found to conveniently afford the corresponding 3-SCF2H-substituted chromones. The combining use of difluoromethyl sulfoxide/Tf2O could represent the first reagents system that can introduce the biologically important SCF2H moiety under base-free conditions via an interrupted Pummerer reaction. The same protocol could also be applied to the synthesis of 3-SCF3-substituted chromones by replacing difluoromethyl sulfoxide with trifluoromethyl sulfoxide and CH3CN with toluene.
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!