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A catalytic system combined with NiBr2 and diphenylphosphine oxide that enabled direct access to the valuable arylacetic acids from inexpensive alkylarenes and H2O via oxidative carbonylation was developed. Alkylarenes with… Click to show full abstract
A catalytic system combined with NiBr2 and diphenylphosphine oxide that enabled direct access to the valuable arylacetic acids from inexpensive alkylarenes and H2O via oxidative carbonylation was developed. Alkylarenes with primary and secondary benzylic C-H bonds were compatible with this method. Remarkably, the marketed drugs ibuprofen and diclofenac could be easily obtained by this procedure straightforwardly.
Keywords:
carbonylation alkylarenes;
catalyzed oxidative;
nickel catalyzed;
oxidative carbonylation;
arylacetic acids
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!