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Ligand- and Substrate-Controlled para C-H Borylation of Anilines at Room Temperature.

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A new catalytic method for para borylation of unprotected anilines is described. The catalytic method is developed by designing a new type of ligand framework that enables para borylation at… Click to show full abstract

A new catalytic method for para borylation of unprotected anilines is described. The catalytic method is developed by designing a new type of ligand framework that enables para borylation at room temperature. We showed that whereas previously reported para borylation of 2-substituted anilines required multistep protection/deprotection sequences and a high reaction temperature, our method gives a straightforward solution for achieving para borylation without such protection/deprotection chemistry at room temperature.

Keywords: borylation; room temperature; ligand substrate; para borylation

Journal Title: Organic letters
Year Published: 2022

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