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Collective Total Syntheses of Benzo[c]phenanthridine Alkaloids via a Sequential Transition Metal-Catalyzed Pot-Economic Approach.

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Collective total syntheses of 10 benzo[c]phenanthridines were achieved on the basis of the construction of rings C and B through sequential transition metal-catalyzed reactions and flexible condition-controlled Mannich reaction via… Click to show full abstract

Collective total syntheses of 10 benzo[c]phenanthridines were achieved on the basis of the construction of rings C and B through sequential transition metal-catalyzed reactions and flexible condition-controlled Mannich reaction via three pots in 25-34% yields, which provided an efficient route to benzo[c]phenanthridines via a pot-economic approach.

Keywords: sequential transition; transition metal; total syntheses; syntheses benzo; metal catalyzed; collective total

Journal Title: Organic letters
Year Published: 2022

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