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Hydroacylation of alkynes is undoubtedly the simplest and most atom-efficient approach for the synthesis of enones with diverse synthetic applications. Despite significant progress in hydroacylations, no hydroacylations exist that make… Click to show full abstract
Hydroacylation of alkynes is undoubtedly the simplest and most atom-efficient approach for the synthesis of enones with diverse synthetic applications. Despite significant progress in hydroacylations, no hydroacylations exist that make use of aldehydes without a chelating group, especially when combined with terminal alkynes. Here we report a synergistic nickel-photocatalytic system that allows for the highly regio- and stereoselective hydroacylation of unactivated aldehydes and alkynes in milder conditions without the use of chelating groups.
Journal Title: Organic letters
Year Published: 2022
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